Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/28996
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Sakač Marija | - |
dc.contributor.author | Nikolić Andrea | - |
dc.contributor.other | Đurendić Evgenija | - |
dc.contributor.other | Sakač Marija | - |
dc.contributor.other | Penov-Gaši Katarina | - |
dc.contributor.other | Jovanović-Šanta Suzana | - |
dc.contributor.other | Đilas Sonja | - |
dc.date.accessioned | 2020-12-14T16:09:17Z | - |
dc.date.available | 2020-12-14T16:09:17Z | - |
dc.date.issued | 2014-04-25 | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/28996 | - |
dc.description.abstract | <p>Cilj ove doktorske disertacije je bila sinteza novih steroidnih 16,17-seko-16,17a-dinitrila polazeći od dehidroepiandrosterona (1), odnosno estrona (14). U androstanskoj seriji su izvršene modifikacije 16,17-seko-16,17a-dinitrila 12 u A i/ili B prstenu steroidnog jezgra, pri čemu novosintetizovana jedinjenja sadrže 4-en-3-on, 1,4-dien-3-on ili 1,4,6-trien-3-on sistem, kao i supstituente u položajima C-4, odnosno C-6 (6-metilen, 6-keto i 6-oksimino). U radu je takođe proučavan uticaj odabranih novosintetizovanih jedinjenja na proliferaciju sedam ćelijskih linija humanih tumora, dok je kao kontrola služila jedna zdrava humana ćelijska linija.</p> | sr |
dc.description.abstract | <p>Starting from dehydroepiandrosterone (1) or estrone (14) new steroidal 16,17-seco-16,17a-dinitriles were synthesized. Modification of 16,17-seco-16,17a-dinitrile 12 afforded androstane derivatives containing 4-en-3-on, 1,4-dien-3-on or 1,4,6-trien-3-on system, with different substituents on position C-4 or C-6 (6-methylene, 6-keto i 6-oximino). Antiproliferative activity of some newly synthesized compounds were examined against seven human tumor cell lines, while healthy cells served as control.</p> | en |
dc.language.iso | sr (latin script) | - |
dc.publisher | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu | sr |
dc.publisher | University of Novi Sad, Faculty of Sciences at Novi Sad | en |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.subject | Synthesis, steroids, androgen, D-seco derivatives, dinitrile, cytotoxicity | en |
dc.subject | Sinteza, steroidi, androgeni, D-seko derivati, dinitrili, citotoksičnost | sr |
dc.title | Synthesis of new steroidal compounds of potentialbiomedical importance | en |
dc.title | Sinteza novih steroidnih jedinjenja od potencijalnog biomedicinskog značaja | sr |
dc.type | Thesis | en |
dc.identifier.url | https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija139384826520860.pdf?controlNumber=(BISIS)85590&fileName=139384826520860.pdf&id=1446&source=BEOPEN&language=en | en |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=85590&source=BEOPEN&language=en | en |
dc.identifier.externalcrisreference | (BISIS)85590 | - |
dc.source.institution | Prirodno-matematički fakultet u Novom Sadu | sr |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | PMF Teze/Theses |
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