Evaluation of Lipid Parameters and Bioindexes in Patitients with Different Stages of Chronic Renal Failure,

Abstract

Background/Aim. Cardiovascular morbidity and mortalityare markedly increased in chronic renal failure (CRF). Theaim of this study was to evaluate lipid parameters and bioin-dices in patients with different stages of CRF. Methods. In46 hemodialysed (HD), 50 CRF patients with II, III and IVstage of CRF (non-HD) and 48 control subjects triglycerides(TG), total cholesterol (C), HDL-C, urea, creatinine, creatin-uria (standard biochemical methods), apolipoprotein (apo) A-I, apo B, lipoprotein(a), cystatin C (immunoturbidimetricmethod) were evaluated, and LDL-C, non-HDL-C, LDL-C/HDL-C, non-HDL-/HDL-C, TG/HDL-C, and newbioindices, LTI (lipid tetrad index), logLTI, LPI (lipid pentadindex), logLPI, AIP (atherogenic index of plasma), and cre-atinine clearance were calculated. Results. There were signifi-cant differences in the levels of TG, HDL-C, LDL-C, non-HDL-C, total C and apo A-I between the HD and non-HDpatients, and the HD patients and the controls. LTI and LPIwere significantly higher in the HD and non-HD patientscompared to the controls (p < 0.05), without a good separa-tion by the Box-Whisker plots. The values of TG/HDL-Cratio and AIP were significantly higher in the HD and non-HD-patients compared to the controls (p < 0.05), and sig-nificantly higher in the HD compared to non-HD patients(p < 0.05). AIP > 0.11 was found in 71.7% of the HD, 56%of non-HD and 31.3% of the controls. Conclusion.Among lipid parameters and indices, AIP and TG/HDL-Cratio are most suitable for evaluation of lipid disturbances indifferent stages of CRF. In addition to, non-HDL-/HDL-C,and apoB/A-I ratios, apo A-I, HDL-C and TG are importantmarkers in HD patients. Non-HDL-C is not a suitablemarker. LTI and LPI need to be further investigated.