Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/26786
DC Field | Value | Language |
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dc.contributor.author | Ičević Ivana | - |
dc.contributor.author | Vukmirović Saša | - |
dc.contributor.author | Srđenović Branislava | - |
dc.contributor.author | Sudji Jan | - |
dc.contributor.author | Đorđević Aleksandar | - |
dc.contributor.author | Injac Rade | - |
dc.contributor.author | Vasović Velibor | - |
dc.date.accessioned | 2020-12-13T21:08:04Z | - |
dc.date.available | 2020-12-13T21:08:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0367-598X | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/26786 | - |
dc.description.abstract | Polyhydroxylated, water soluble, fullerenol C60(OH)24 nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity. The goal of this work was to investigate the potential protective effects of orally applied FNP on rats after a single dose of doxorubicin (DOX) (8 mg/kg (i.p.)) 6 h after the last application of FNP. After the last drug administration, the rats were sacrificed, and the blood and tissues were taken for the analysis. Biochemical and pathological results obtained in this study indicate that fullerenol (FNP), in H2O:dimethyl sulfoxide (DMSO) (80:20, w/w) solution given orally in final doses of 10, 14.4, and 21.2 mg/kg, three days successively, has the protective (hepatoprotective and nephroprotective) effect against doxorubicin-induced cytotoxicity via its antioxidant properties. | en |
dc.language.iso | en | - |
dc.relation.ispartof | Hemijska industrija | sr |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.subject | Fullerenol • Nano particles • Doxorubicine • In vivo • Oral application | en |
dc.title | Protective effects of orally applied fullerenol nano particles in rats after a single dose of doxorubicin | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=67695&source=BEOPEN&language=en | en |
dc.relation.lastpage | 337 | - |
dc.relation.firstpage | 329 | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 65 | - |
dc.identifier.externalcrisreference | (BISIS)67695 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmakologiju i toksikologiju | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmakologiju i toksikologiju | - |
crisitem.author.orcid | 0000-0003-4120-7318 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
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