Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/2667
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pejin B. | en |
dc.contributor.author | Tommonaro G. | en |
dc.contributor.author | Glumac M. | en |
dc.contributor.author | Jakimov D. | en |
dc.contributor.author | Kojić, Vesna | en |
dc.date.accessioned | 2019-09-23T10:22:56Z | - |
dc.date.available | 2019-09-23T10:22:56Z | - |
dc.date.issued | 2018-03-04 | en |
dc.identifier.issn | 14786419 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/2667 | - |
dc.description.abstract | © 2017 Informa UK Limited, trading as Taylor & Francis Group. This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 μM (IC50 0.68 ± 0.04 μM, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 μM), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. | en |
dc.relation.ispartof | Natural Product Research | en |
dc.title | The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.doi | 10.1080/14786419.2017.1327959 | en |
dc.identifier.pmid | 32 | en |
dc.identifier.scopus | 2-s2.0-85019215056 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85019215056 | en |
dc.relation.lastpage | 620 | en |
dc.relation.firstpage | 616 | en |
dc.relation.issue | 5 | en |
dc.relation.volume | 32 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
Appears in Collections: | MDF Publikacije/Publications |
SCOPUSTM
Citations
8
checked on May 10, 2024
Page view(s)
20
Last Week
7
7
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.