Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/22890
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jovanović-Šanta Suzana | - |
dc.contributor.author | Andric Silvana | - |
dc.contributor.author | Kovacevic Radmila | - |
dc.contributor.author | Pejanovic V. | - |
dc.date.accessioned | 2020-12-13T17:01:20Z | - |
dc.date.available | 2020-12-13T17:01:20Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0010-0765 | - |
dc.identifier.issn | 1212-6950 | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/22890 | - |
dc.description.abstract | Starting from estrone 3-benzyloxy-17β-hydroxyestra-1,3,5(10)-trien-16-one oxime (3b) was synthesized, which underwent Beckmann fragmentation giving the 3-benzyloxy-17-oxo-16,17-secoestra-1,3,5(10)-triene-16-nitrile (4b). Sodiumb borohydride reduction of this compound afforded 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile (5b). The deprotection of the 3-hydroxy group was achieved by action of hydrogen upon derivatives 4b and 5b in presence of Pd/C as a catalyst, yielding 3-hydroxy-17-oxo-16,17-secoestra-1,3,5(10)-triene-16-nitrile (4a) and 3,17-dihydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile (5a). In biological tests on experimental animals, compounds 4a, 4b, 5a and 5b showed virtually a complete loss of estrogenic activity, whereas compounds 4a, 5a and 5b exhibited moderate antiestrogenic effect. | - |
dc.relation.ispartof | Collection of Czechoslovak Chemical Communications | - |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.title | Synthesis and biological activity of new 16, 17-secoestrone derivatives | - |
dc.type | Journal/Magazine Article | - |
dc.identifier.doi | 10.1135/cccc20000077 | - |
dc.identifier.scopus | 2-s2.0-0034366320 | - |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=18595&source=BEOPEN&language=en | - |
dc.relation.lastpage | 82 | - |
dc.relation.firstpage | 77 | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 65 | - |
dc.identifier.externalcrisreference | (BISIS)18595 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za biologiju i ekologiju | - |
crisitem.author.orcid | 0000-0002-4579-5762 | - |
crisitem.author.orcid | 0000-0002-2908-8136 | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
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