Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/20314
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bjelogrlić Snežana | - |
dc.contributor.author | Todorović Tamara R. | - |
dc.contributor.author | Cvijetić Ilija | - |
dc.contributor.author | Rodić Marko | - |
dc.contributor.author | Vujčić Miroslava | - |
dc.contributor.author | Marković Sanja | - |
dc.contributor.author | Araškov Jovana | - |
dc.contributor.author | Janović Barbara | - |
dc.contributor.author | Emhemmed Fathi | - |
dc.contributor.author | Muller Christian D. | - |
dc.contributor.author | Filipović Nenad R. | - |
dc.date.accessioned | 2020-12-13T14:35:09Z | - |
dc.date.available | 2020-12-13T14:35:09Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0162-0134 | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/20314 | - |
dc.description.abstract | © 2018 Elsevier Inc. A novel binuclear Cd complex (1) with hydrazone-based ligand was prepared and characterized by spectroscopy and single crystal X-ray diffraction techniques. Complex 1 reveals a strong pro-apoptotic activity in both human, mammary adenocarcinoma cells (MCF-7) and pancreatic AsPC-1 cancer stem cells (CSCs). While apoptosis undergoes mostly caspase-independent, 1 stimulates the activation of intrinsic pathway with noteworthy down regulation of caspase-8 activity in respect to non-treated controls. Distribution of cells over mitotic division indicates that 1 caused DNA damage in both cell lines, which is confirmed in DNA interaction studies. Compared to 1, cisplatin (CDDP) does not achieve cell death in 2D cultured AsPC-1 cells, while induces different pattern of cell cycle changes and caspase activation in 2D cultured MCF-7 cells, implying that these two compounds do not share similar mechanism of action. Additionally, 1 acts as a powerful inducer of mitochondrial superoxide production with dissipated trans-membrane potential in the majority of the treated cells already after 6 h of incubation. On 3D tumors, 1 displays a superior activity against CSC model, and at 100 μM induces disintegration of spheroids within 2 days of incubation. Fluorescence spectroscopy, along with molecular docking show that compound 1 binds to the minor groove of DNA. Compound 1 binds to the human serum albumin (HSA) showing that the HSA can effectively transport and store 1 in the human body. Thus, our current study strongly supports further investigations on antitumor activity of 1 as a drug candidate for the treatment of highly resistant pancreatic cancer. | en |
dc.language.iso | en | - |
dc.relation.ispartof | Journal of Inorganic Biochemistry | en |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.title | A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.doi | 10.1016/j.jinorgbio.2018.10.002 | - |
dc.identifier.scopus | 85055090720 | - |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=113773&source=BEOPEN&language=en | en |
dc.relation.lastpage | 66 | - |
dc.relation.firstpage | 45 | - |
dc.relation.volume | 190 | - |
dc.identifier.externalcrisreference | (BISIS)113773 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.orcid | 0000-0002-4471-8001 | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
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