Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/17547
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bogdanović, Gordana | en_US |
dc.contributor.author | Kojić, Vesna | en_US |
dc.contributor.author | Đorđević, Aleksandar | en_US |
dc.contributor.author | Čanadanović-Brunet, Jasna | en_US |
dc.contributor.author | Vojinović-Miloradov, Mirjana | en_US |
dc.contributor.author | Baltić, Vladimir | en_US |
dc.date.accessioned | 2020-12-13T11:50:57Z | - |
dc.date.available | 2020-12-13T11:50:57Z | - |
dc.date.issued | 2004-10-01 | - |
dc.identifier.issn | 08872333 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/17547 | - |
dc.description.abstract | Paper presents the effects of the newly synthesized fullerol C60(OH)22 on the growth of tumor cells in vitro and its modulating activity on doxorubicin (DOX)-induced cytotoxicity in human breast cancer cell lines. Cell growth inhibition was evaluated by tetrazolium colorimetric WST1 assay. Electron spin resonance (ESR) “trapping” method was used to investigate OH-radical scavenger activity of fullerol during Fenton's reaction. At a range of nanomolar concentrations fullerol induced cell growth inhibition, which was cell line, dose and time dependent. Fullerol also strongly suppressed DOX-induced cytotoxicity at all concentrations regardless the time of fullerol addition. Proanthocyanidins added as single agent to MCF-7 cell culture for 48 h induced low growth inhibition but in combination with DOX strongly decreased DOX cytotoxicity. Fullerol was found to be a potent hydroxyl radical scavenger: the relative intensity of ESR signals of DMPO-hydroxyl radical (DMPO-OH) spin adduct decreased by 88% in the presence of 0.5 μg/ml of fullerol. The obtained results suggest that antiproliferative effect of the fullerol and its protective effect on DOX-induced cytotoxicity might be mediated through hydroxyl-radical scavenger activity of C60(OH)22. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Toxicology in Vitro | en_US |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.title | Modulating activity of fullerol C60(OH)22 on doxorubicin-induced cytotoxicity | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | (BISIS)10414 | - |
dc.identifier.doi | (BISIS)10414 | - |
dc.identifier.doi | (BISIS)10414 | - |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=10414&source=BEOPEN&language=en | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 637 | en_US |
dc.relation.firstpage | 629 | en_US |
dc.relation.issue | 5 | en_US |
dc.relation.volume | 18 | en_US |
dc.identifier.externalcrisreference | (BISIS)10414 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za primenjene i inženjerske hemije | - |
crisitem.author.orcid | 0000-0003-4120-7318 | - |
crisitem.author.orcid | 0000-0003-1154-1366 | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
Appears in Collections: | TF Publikacije/Publications |
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