Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/15909
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mooranian A. | en_US |
dc.contributor.author | Zamani N. | en_US |
dc.contributor.author | Takechi R. | en_US |
dc.contributor.author | Al-Sallami H. | en_US |
dc.contributor.author | Momir Mikov | en_US |
dc.contributor.author | Svetlana Goločorbin-Kon | en_US |
dc.contributor.author | Božica Kovačević | en_US |
dc.contributor.author | Arfuso F. | en_US |
dc.contributor.author | Al-Salami H. | en_US |
dc.date.accessioned | 2020-03-03T15:01:51Z | - |
dc.date.available | 2020-03-03T15:01:51Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.issn | 20415990 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/15909 | - |
dc.description.abstract | © 2019 Newlands Press. Aim: Common features in insulin-resistance diabetes include inflammation and liver damage due to bile acid accumulation. Results & methodology: This study aimed to test in vivo pharmacological effects of combining two drugs, ursodeoxycholic acid that has bile acid regulatory effects, and probucol (PB) that has potent anti-oxidative stress effects, using a new poly(meth)acrylate nano-targeting formulation on prediabetic mice. Mice were made diabetic and were fed daily with either PB, nanoencapsulated PB or nanoencapsulated PB-ursodeoxycholic acid before blood, tissues, urine and feces were collected for inflammation and bile acid measurements. The nanoencapsulated PB-ursodeoxycholic acid formulation increased plasma IL-10, and increased the concentration of primary bile acids in the liver and heart. Conclusion: Results suggest potential applications in regulating IL-10 in insulin-resistance prediabetes. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Therapeutic Delivery | en_US |
dc.subject | insulin resistance | en_US |
dc.subject | diabetes | en_US |
dc.subject | nanoencapsulation | en_US |
dc.subject | probucol | en_US |
dc.subject | bile acids | en_US |
dc.title | Probucol-poly(meth)acrylate-bile acid nanoparticles increase IL-10, and primary bile acids in prediabetic mice | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.4155/tde-2019-0052 | - |
dc.identifier.pmid | 10 | - |
dc.identifier.scopus | 2-s2.0-85074527921 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85074527921 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 571 | en_US |
dc.relation.firstpage | 563 | en_US |
dc.relation.issue | 9 | en_US |
dc.relation.volume | 10 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.orcid | https://orcid.org/0000-0002-9257-8074 | - |
Appears in Collections: | MDF Publikacije/Publications |
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