Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/15714
Pоljе DC-а | Vrеdnоst | Јеzik |
---|---|---|
dc.contributor.author | Milić, Dragan | en |
dc.contributor.author | Kapor A. | en |
dc.contributor.author | Markov B. | en |
dc.contributor.author | Ribar B. | en |
dc.contributor.author | Strümpel M. | en |
dc.contributor.author | Juranić Z. | en |
dc.contributor.author | Gašić M. | en |
dc.contributor.author | Šolaja B. | en |
dc.date.accessioned | 2020-03-03T15:01:03Z | - |
dc.date.available | 2020-03-03T15:01:03Z | - |
dc.date.issued | 1999-01-01 | en |
dc.identifier.issn | 14203049 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/15714 | - |
dc.description.abstract | Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed structure was established by X-ray analysis revealing two symmetry independent molecules in the asymmetric unit each consisting of four fused rings with the C(10) β-oriented hydroxy group and β-oriented O atom bridging C(4) and C(5). The conformation of A ring in both conformers A and B is boat (B3,6 ), while rings B and C are chairs (1C4) and the five-membered D ring is in an envelope (E2) conformation. The in vitro antitumor activity of title compound and its 17β-acetoxy analogue against HeLa and Fem-x cells revealed IC50 values of 5.7 and 7.1 μM, and 2.25 and 1.58 μM, respectively. Corresponding quinols were tested on 47 cell lines with 10β-hydroxy-17β-acetoxyestra-1,4-dien-3-one being most active against leukemia SR cells (GI50 = 0.17 μM). | en |
dc.relation.ispartof | Molecules | en |
dc.title | X-ray crystal structure of 10β-hydroxy-4β,5β-epoxyestr-1-en3,17-dione and antitumor activity of its congeners | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.doi | 10.3390/41200338 | en |
dc.identifier.scopus | 2-s2.0-0000703525 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/0000703525 | en |
dc.relation.lastpage | 352 | en |
dc.relation.firstpage | 338 | en |
dc.relation.issue | 12 | en |
dc.relation.volume | 4 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Departman za ekonomiku poljoprivrede i sociologiju sela | - |
crisitem.author.parentorg | Poljoprivredni fakultet | - |
Nаlаzi sе u kоlеkciјаmа: | POLJF Publikacije/Publications |
SCOPUSTM
Nаvоđеnjа
9
prоvеrеnо 20.11.2023.
Prеglеd/i stаnicа
31
Prоtеklа nеdеljа
1
1
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.