Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/15231
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dc.contributor.authorGordana Bogdanovićen_US
dc.contributor.authorVladimir Jurišićen_US
dc.contributor.authorNada Kraguljacen_US
dc.contributor.authorJasminka Mrđanovićen_US
dc.contributor.authorDimitar Jakimoven_US
dc.contributor.authorKoviljka Krtolicaen_US
dc.contributor.authorMilena Krajnovićen_US
dc.contributor.authorZvonko Magićen_US
dc.contributor.authorBratislav Stojiljkovićen_US
dc.contributor.authorLjiljana Andrijevićen_US
dc.contributor.authorTatjana Srdićen_US
dc.contributor.authorMirjana Baltićen_US
dc.contributor.authorStevan Popovićen_US
dc.date.accessioned2020-03-03T14:59:08Z-
dc.date.available2020-03-03T14:59:08Z-
dc.date.issued2007-01-01-
dc.identifier.issn1452126en_US
dc.identifier.urihttps://open.uns.ac.rs/handle/123456789/15231-
dc.description.abstractWe report on characteristics of the first human cell line, PC-MDS, derived from a bone marrow of a patient with therapy-related myelodysplastic syndrome (t-MDS) who had no overt post-MDS leukemia. Classic cytology analyses, immunophenotyping, cytogenetic and molecular genetic procedures were used for characterization of the cell line. PC-MDS cells are positive for the expression of CD13, CD15, CD30, CD33, and CD45 antigen. Positive cytochemical staining and immunophenotype analyses indicated that PC-MDS cells have some characteristics of the early myeloid precursor cell. The karyotype analysis of PC-MDS cell line revealed various numerical and structural changes including those typically associated with t-MDS: del(5)(q13)[7], der(5)t(5;11)(p11;q11)[13], -7[6], del(7)(q31)[2], +20[3], -20[4]. Evaluation of methylation status in a promoter region of p15, p16 and MGMT genes showed biallelic hypermethylation pattern of 5′ promoter region only in MGMT gene. PC-MDS is the first t-MDS derived cell line, and based on its immunological, cytogenetic and molecular characterization could be a new tool in evaluation of complex biology of MDS and a model for methylation studies. © 2007 Elsevier Ltd. All rights reserved.en_US
dc.language.isoenen_US
dc.relation.ispartofLeukemia Researchen_US
dc.subjecthuman cell lineen_US
dc.subjectcytogeneticen_US
dc.subjectimmunophenotypeen_US
dc.subjectmethylation statusen_US
dc.subjectIg and TCR gene rearrangementsen_US
dc.titleCharacteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndromeen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.doi10.1016/j.leukres.2007.01.012-
dc.identifier.pmid31-
dc.identifier.scopus2-s2.0-34249939084-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/34249939084-
dc.description.versionPublisheden_US
dc.relation.lastpage1105en_US
dc.relation.firstpage1097en_US
dc.relation.issue8en_US
dc.relation.volume31en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptMedicinski fakultet, Katedra za biohemiju-
crisitem.author.orcid0000-0003-0676-7985-
crisitem.author.parentorgMedicinski fakultet-
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