Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/14569
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leskovac V. | en |
dc.contributor.author | Popović M. | en |
dc.date.accessioned | 2020-03-03T14:56:37Z | - |
dc.date.available | 2020-03-03T14:56:37Z | - |
dc.date.issued | 1980-01-01 | en |
dc.identifier.issn | 00316989 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/14569 | - |
dc.description.abstract | Reduction of the nitro-group of nitrofurantoin /N-[5-Nitro-2-furfuryliden-] 1-aminohydantoin/ on liver microsomes is supported both by NADPH and NADH. The site of interaction of nitrofurantoin with microsomes appears to be on two flavoproteins, NADPH-cytochrome P450 reductase and NADH-cytochrome b5 reductase; interaction with the former enzyme is much stronger then with the later. Cytochromes P450 and b5 are not the sites of nitro-reduction. Aerobic and anaerobic fate of nitro-group is different. Under aerobic conditions, nitrofurantoin serves as a cyclic catalyst for the HAD/P/H-supported reduction of molecular oxygen to water; it becomes only catalytically reduced to nitro-anion free radical. Under anaerobic conditions, nitrofurantoin is permanently reduced by NAD/P/H; we were able to identify two successive reduction products of nitro-group, nitroso- and hydroxylamine-group. Normal redox potential of the nitro/nitroso redox couple is approx. O.O Volts. Under physiological conditions, nitrofurantoin, in addition to its transformations into stable reduction products, has a substantial draining effect on the HADPH-, NADH- and O2-pool in liver cells. A stronger cytotoxicity of nitrofurantoin should be expected under aerobic, compared to anaerobic conditions. © 1980 The Italian Pharmacological Society. | en |
dc.relation.ispartof | Pharmacological Research Communications | en |
dc.title | Mechanism of reduction of nitrofurantoin on liver microsomes | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.doi | 10.1016/S0031-6989(80)80058-0 | en |
dc.identifier.pmid | 12 | en |
dc.identifier.scopus | 2-s2.0-0018844998 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/0018844998 | en |
dc.relation.lastpage | 27 | en |
dc.relation.firstpage | 13 | en |
dc.relation.issue | 1 | en |
dc.relation.volume | 12 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | TF Publikacije/Publications |
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