Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/14403
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ivan Kuhajda | en_US |
dc.contributor.author | Mihalj Poša | en_US |
dc.contributor.author | Vida Jakovljević | en_US |
dc.contributor.author | Vesna Ivetić | en_US |
dc.contributor.author | Momir Mikov | en_US |
dc.date.accessioned | 2020-03-03T14:56:03Z | - |
dc.date.available | 2020-03-03T14:56:03Z | - |
dc.date.issued | 2009-04-01 | - |
dc.identifier.issn | 3787966 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/14403 | - |
dc.description.abstract | This work is concerned with the potential promotive action of 12-monoketocholic acid (12-MKC) on the analgesic effect of morphine and tramadol. The investigation was carried out on laboratory Wistar rats divided into five test groups, each treated with either morphine (2 mg/kg), tramadol (9.6 mg/kg), 12-MKC (2 mg/kg), morphine + 12-MKC, or tramadol + 12-MKC, the control group receiving physiological solution (2 mg/kg). The effect of 12-MKC on the analgesic action of morphine and tramadol was determined by radiation heat method. Morphine and tramadol, given in equimolar doses, did not show significant difference in the degree of analgesia. In combination with morphine, 12-MKC increased significantly the analgesic effect compared with the group treated with morphine alone. However, 12-MKC caused no change in the action of tramadol. The 5-day intravenous application of 12-MKC in combination with the two analgesics caused no changes in the biochemical parameters nor pathohistological changes in the liver parenchyma of tested animals. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | European Journal of Drug Metabolism and Pharmacokinetics | en_US |
dc.subject | 12-monoketocholic acid | en_US |
dc.subject | morphine | en_US |
dc.subject | tramadol | en_US |
dc.subject | analgesic effect | en_US |
dc.subject | blood-brain barrier | en_US |
dc.title | Effect of 12-monoketocholic acid on modulation of analgesic action of morphine and tramadol | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1007/BF03191154 | - |
dc.identifier.pmid | 34 | - |
dc.identifier.scopus | 2-s2.0-68949110442 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/68949110442 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 78 | en_US |
dc.relation.firstpage | 73 | en_US |
dc.relation.issue | 2 | en_US |
dc.relation.volume | 34 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Katedra za hirurgiju | - |
crisitem.author.dept | Katedra za farmaciju | - |
crisitem.author.orcid | 0000-0002-8044-2655 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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