Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/13808
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thurnher M. | en_US |
dc.contributor.author | Jasmina Boban | en_US |
dc.contributor.author | Rieger A. | en_US |
dc.contributor.author | Gelpi E. | en_US |
dc.date.accessioned | 2020-03-03T14:53:47Z | - |
dc.date.available | 2020-03-03T14:53:47Z | - |
dc.date.issued | 2019-06-01 | - |
dc.identifier.issn | 1956108 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/13808 | - |
dc.description.abstract | © 2019 American Society of Neuroradiology. All rights reserved. BACKGROUND AND PURPOSE: Progressive multifocal leukoencephalopathy (PML) represents a life-threatening demyelinating disorder of the brain caused by reactivation of a rare opportunistic infection with JC Polyomavirus. The aims of this study were to describe the incidence of a susceptibility-weighted imaging hypointense rim in patients with multifocal leukoencephalopathy and to explore the histologic correlates and prognostic value of the rim with regard to the clinical outcome. MATERIALS AND METHODS: This retrospective study included 18 patients with a definite diagnosis of progressive multifocal leukoencephalopathy. Ten patients were HIV-positive, 3 patients had natalizumab-associated progressive multifocal leukoencephalopathy, 1 patient had multiple myeloma, 3 patients had a history of lymphoma, and 1 was diagnosed with acute myeloid leukemia. Patients were divided into short-(up to 12 months) and long-term (12 months) survivors. A total of 93 initial and follow-up MR imaging examinations were reviewed. On SWI, the presence and development of a hypointense rim at the periphery of the progressive multifocal leukoencephalopathy lesions were noted. A postmortem histologic examination was performed in 2 patients: A rim formed in one, and in one, there was no rim. RESULTS: A total of 73 progressive multifocal leukoencephalopathy lesions were observed. In 13 (72.2%) patients, a well-defined thin, linear, hypointense rim at the periphery of the lesion toward the cortical side was present, while in 5 (27.8%) patients, it was completely absent. All 11 long-term survivors and 2 short-term survivors presented with a prominent SWI-hypointense rim, while 5/7 short-term survivors did not have this rim. CONCLUSIONS: The thin, uniformly linear, gyriform SWI-hypointense rim in the paralesional U-fibers in patients with definite progressive multifocal leukoencephalopathy might represent an end-point stage of the neuroinflammatory process in long-term survivors. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | American Journal of Neuroradiology | en_US |
dc.subject | Leukoencephalopathy | en_US |
dc.subject | MRI | en_US |
dc.title | Susceptibility-weighted MR imaging hypointense rim in progressive multifocal leukoencephalopathy: The end point of neuroinflammation and a potential outcome predictor | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.3174/ajnr.A6072 | - |
dc.identifier.pmid | 40 | - |
dc.identifier.scopus | 2-s2.0-85068198245 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85068198245 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 1000 | en_US |
dc.relation.firstpage | 994 | en_US |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 40 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za radiologiju | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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