Effect of the aluminium ion on hepatic elimination of quinine and quinidine

Abstract

A study of the influence of the aluminium ion on the blood and hepatic kinetics of two alkaloid stereoisomers - quinine and quinidine - after their p.o and s.c. administration (80 mg/kg) to rats was carried out. It appeared that the mode of application of the stereoisomers had different effects on their resorbtion in control animals. In the case of s.c. application, blood concentrations of quinine in some time intervals reached significantly higher levels than those found for quinidine. Hepatic elimination of quinine appeared to be independent of the mode of its application, whereas the elimination of quinidine was significantly increased after its s.c. application. Pretreatment of rats with aluminium chloride (600 mg/kg, i.p.) 2 h before injecting one of the stereoisomers had a different effect on their concentrations in blood, and significantly higher effect on their bile elimination. The quinine concentrations in blood after its p.o. administration were not changed significantly, but after s.c. application these concentrations were increased in some time intervals. The presence of the aluminium ion caused a significant increase in the rate of hepatic elimination of quinine, whereas it had no significant effect on quinidine elimination. © 1995 Springer-Verlag.