Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole

Abstract

We investigated the rat brain activity in acute seizures evoked by camphor essential oil or its main constituent 1,8-cineole by wavelet (primarily) and fractal analysis. Experiments were performed on anesthetized animals before and after intraperitoneal camphor oil or cineole administration. The properties of frequency bands in pre-ictal, ictal and inter-ictal stages have been determined by wavelet analysis. The domination of δ frequency band was confirmed in obtained brain activities, which participate with ≈45% of mean relative wavelet energy (MRWE) in control signals and arise up to ≈76% MRWE in energy spectrum during the ictal stage (after drug administration). Other frequency bands decreased during ictal stage and arised in inter-ictal stage. There was a dose-dependent response of cineole effect: increase in cineole concentration leaded to the higher values of relative wavelet energy (RWE) of δ frequency band while there were slight changes of the mean fractal dimension (FD) values as a measure of system complexity.