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https://open.uns.ac.rs/handle/123456789/1270
Pоljе DC-а | Vrеdnоst | Јеzik |
---|---|---|
dc.contributor.author | Otto Barak | en_US |
dc.contributor.author | Caljkusic K. | en_US |
dc.contributor.author | Hoiland R. | en_US |
dc.contributor.author | Ainslie P. | en_US |
dc.contributor.author | Thom S. | en_US |
dc.contributor.author | Yang M. | en_US |
dc.contributor.author | Jovanov P. | en_US |
dc.contributor.author | Dujic Z. | en_US |
dc.date.accessioned | 2019-09-23T10:14:36Z | - |
dc.date.available | 2019-09-23T10:14:36Z | - |
dc.date.issued | 2018-10-01 | - |
dc.identifier.issn | 0363-6119 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/1270 | - |
dc.description.abstract | We examined if the diving-induced vascular changes in the peripheral and cerebral circulation could be prevented by oral antioxidant supplementation. Fourteen divers performed a single scuba dive to eighteen meter sea water for 47 min. Twelve of the divers participated in a follow-up study involving breathing 60% of oxygen at ambient pressure for 47 min. Before both studies, participants ingested vitamin C (2 g/day) or a placebo capsule for 6 days. After a 2-wk washout, the study was repeated with the different condition. Endothelium-dependent vasodilator function of the brachial artery was assessed pre- and postintervention using the flow-mediated dilation (FMD) technique. Transcranial Doppler ultrasound was used to measure intracranial blood velocities pre- and 90 min postintervention. FMD was reduced by ∼32.8% and ∼21.2% postdive in the placebo and vitamin C trial and posthyperoxic condition in the placebo trial by ∼28.2% ( P < 0.05). This reduction in FMD was attenuated by ∼10% following vitamin C supplementation in the hyperoxic study ( P > 0.05). Elevations in intracranial blood velocities 30 min after surfacing from diving were reduced in the vitamin C study compared with the placebo trial ( P < 0.05). O2 breathing had no postintervention effects on intracranial velocities ( P > 0.05). Prophylactic ingestion of vitamin C effectively abrogated peripheral vascular dysfunction following exposure to 60% O2 but did not abolish the postdive decrease in FMD. Transient elevations of intracranial velocities postdive were reduced by vitamin C. These findings highlight the differential influence of vitamin C on peripheral and cerebral circulations following scuba diving, which are only partly mediated via hyperoxia. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | American journal of physiology. Regulatory, integrative and comparative physiology | en_US |
dc.subject | cerebral blood flow | en_US |
dc.subject | flow-mediated dilation | en_US |
dc.subject | hyperoxia | en_US |
dc.subject | transcranial Doppler ultrasound | en_US |
dc.title | Differential influence of vitamin C on the peripheral and cerebral circulation after diving and exposure to hyperoxia | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1152/ajpregu.00412.2017 | - |
dc.identifier.pmid | 29995458 | - |
dc.identifier.scopus | 2-s2.0-85071280735 | - |
dc.identifier.isi | 000447753700018 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85071280735 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | R767 | en_US |
dc.relation.firstpage | R759 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.volume | 315 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Katedra za fiziologiju | - |
crisitem.author.orcid | 0000-0001-6727-8304 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
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