Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/12290
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dc.contributor.authorPopović J.en
dc.contributor.authorAtanacković M.en
dc.contributor.authorPilipović A.en
dc.contributor.authorRapaić, Milanen
dc.contributor.authorPilipović, Stevanen
dc.contributor.authorAtanacković T.en
dc.date.accessioned2020-03-03T14:47:53Z-
dc.date.available2020-03-03T14:47:53Z-
dc.date.issued2010-01-01en
dc.identifier.issn1567567Xen
dc.identifier.urihttps://open.uns.ac.rs/handle/123456789/12290-
dc.description.abstractThis study presents a new two compartmental model and its application to the evaluation of diclofenac pharmacokinetics in a small number of healthy adults, during a bioequivalence trial. In the model the integer order derivatives are replaced by derivatives of real order often called fractional order derivatives. Physically that means that a history (memory) of a biological process, realized as a transfer from one compartment to another one with the mass balance conservation, is taken into account. This kind of investigations in pharmacokinetics is founded by Dokoumetzidis and Macheras through the one compartmental models while our contribution is the analysis of multi-dimensional compartmental models with the applications of the two compartmental model in evaluation of diclofenac pharmacokinetics. Two experiments were preformed with 12 healthy volunteers with two slow release 100 mg diclofenac tablet formulations. The agreement of the values predicted by the proposed model with the values obtained through experiments is shown to be good. Thus, pharmacokinetics of slow release diclofenac can be described well by a specific two compartmental model with fractional derivatives of the same order. Parameters in the model are determined by the least-squares method and the Particle Swarm Optimization (PSO) numerical procedure is used. The results show that the fractional order two compartmental model for diclofenac is superior in comparison to the classical two compartmental model. Actually this is true in general case since the classical one is a special case of the fractional one. © Springer Science+Business Media, LLC 2010.en
dc.relation.ispartofJournal of Pharmacokinetics and Pharmacodynamicsen
dc.titleA new approach to the compartmental analysis in pharmacokinetics: Fractional time evolution of diclofenacen
dc.typeJournal/Magazine Articleen
dc.identifier.doi10.1007/s10928-009-9147-3en
dc.identifier.pmid37en
dc.identifier.scopus2-s2.0-77953539358en
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/77953539358en
dc.relation.lastpage134en
dc.relation.firstpage119en
dc.relation.issue2en
dc.relation.volume37en
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptFakultet tehničkih nauka, Departman za računarstvo i automatiku-
crisitem.author.deptPrirodno-matematički fakultet, Departman za matematiku i informatiku-
crisitem.author.orcid0000-0002-5443-4467-
crisitem.author.parentorgFakultet tehničkih nauka-
crisitem.author.parentorgPrirodno-matematički fakultet-
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