Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/1216
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jasmina Boban | en_US |
dc.contributor.author | Duško Kozić | en_US |
dc.contributor.author | Snežana Brkić | en_US |
dc.contributor.author | Dajana Lendak | en_US |
dc.contributor.author | Majda Thurnher | en_US |
dc.date.accessioned | 2019-09-23T10:14:17Z | - |
dc.date.available | 2019-09-23T10:14:17Z | - |
dc.date.issued | 2018-10-18 | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/1216 | - |
dc.description.abstract | © 2018 Boban, Kozic, Brkic, Lendak and Thurnher. Introduction: The aim of this study was to compare age-related changes in chronically infected, asymptomatic HIV-positive patients under combination antiretroviral therapy (cART), with age-, gender-, and educational-level-matched healthy subjects, using multi-voxel magnetic-resonance spectroscopy (MRS). Methods: There were 66 chronically infected HIV-positive subjects and 65 age-, gender-, and educational-level-matched control subjects, divided into four groups according to the age: group 1 (20-29 years old), group 2 (30-39), group 3 (40-49) and group 4 (50-59). MRS was performed and ratios of N-acetyl-aspartate (NAA)/creatine (Cr) were analyzed in ten locations of the supracallosal gray matter. For the comparison of NAA/Cr ratios in healthy and HIV-positive subjects, ANCOVA with age and education as covariates was performed. Correlations of NAA/Cr ratios with duration of cART were performed using Pearson's correlation test. Statistical significance was set at p < 0.05. Results: The NAA/Cr ratios were decreased in the 20-29-year-old HIV-positive subjects in 8/10 locations (p < 0.005) compared to the healthy controls, while in the 50-59-year-old groups they were significiantly lower only in one location (p = 0.004). There were significant positive correlations of NAA/Cr levels with the duration of cART in the oldest group of HIV-positive subjects, while in the youngest group there were no significant correlations. Conclusion: The aging pattern in chronic HIV infection under cART is accentuated rather than accelerated. There is an initial HIV-related neuronal damage with a significant decline in NAA/Cr ratios; after the initiation of cART, however, NAA/Cr ratios increase continuously to become similar to healthy aging individuals, probably due to beneficial effect of long-standing cART. Summary: Brain aging in chronic HIV infection under cART is accentuated, with an initial HIV-related neuronal damage followed by a subtle NAA/Cr increase after the initiation of cART. Under cART, in advanced age, NAA/Cr ratios become similar to healthy aging individuals. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Frontiers in Aging Neuroscience | en_US |
dc.subject | HIV | en_US |
dc.subject | brain | en_US |
dc.subject | MR spectrocopy | en_US |
dc.subject | aging | en_US |
dc.subject | HIV infections | en_US |
dc.title | Early introduction of cART reverses brain aging pattern in well-controlled HIV infection: A comparative MR spectroscopy study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.3389/fnagi.2018.00329 | - |
dc.identifier.scopus | 2-s2.0-85055347085 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85055347085 | - |
dc.description.version | Published | en_US |
dc.relation.issue | OCT | en_US |
dc.relation.volume | 10 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za radiologiju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za radiologiju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za infektivne bolesti | - |
crisitem.author.dept | Medicinski fakultet, Katedra za infektivne bolesti | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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