Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/12163
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nissan A. | en |
dc.contributor.author | Protić, Mlađan | en |
dc.contributor.author | Bilchik A. | en |
dc.contributor.author | Howard R. | en |
dc.contributor.author | Peoples G. | en |
dc.contributor.author | Stojadinović, Aleksandra | en |
dc.date.accessioned | 2020-03-03T14:47:26Z | - |
dc.date.available | 2020-03-03T14:47:26Z | - |
dc.date.issued | 2012-09-01 | en |
dc.identifier.issn | 34932 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/12163 | - |
dc.description.abstract | Objective: Our randomized controlled trial previously demonstrated improved staging accuracy with targeted nodal assessment and ultrastaging (TNA-us) in colon cancer (CC). Our objective was to test the hypothesis that TNA-us improves disease-free survival (DFS) in CC. Methods: In this randomized trial, targeted nodal assessment and ultrastaging resulted in enhanced lymph node diagnostic yield associated with improved staging accuracy, which was further associated with improved disease-free survival in early colon cancer. Results: Clinical parameters of the control (n = 94) and TNA-us (n = 98) groups were comparable. Median (interquartile range) lymph node yield was higher in the TNA-us arm: 16 (12-22) versus 13 (10-18); P = 0.002. Median follow-up was 46 (29-70) months. Overall 5-year DFS was 61% in the control arm and 71% in the TNA-us arm (P = 0.11). Clinical parameters of node-negative patients in the control (n = 51) and TNA-us (n = 55) groups were comparable. Lymph node yield was higher in the TNA-us arm: 15 (12-21) versus 13 (8-18); P = 0.03. Five-year DFS differed significantly between groups with node-negative CC (control 71% vs TNA-us 86%; P = 0.04). Survival among stage II CC alone was higher in the TNA-us group, 83% versus 65%; P = 0.03. Adjuvant chemotherapy use was nearly identical between groups. TNA-us stratified CC prognosis; DFS differed significantly between ultrastaged and conventionally staged node-negative patients [control pN0 72% vs TNA-us pN0(i-) 87%; P = 0.03]. Survival varied according to lymph node yield in patients with node-negative CC [5-year DFS: <12 lymph nodes = 57% vs 12+ lymph nodes = 85%; P = 0.011] but not in stage III CC. Conclusions: TNA-us is associated with improved nodal diagnostic yield and enhanced staging accuracy (stage migration), which is further associated with improved DFS in early CC. © 2012 Lippincott Williams & Wilkins. | en |
dc.relation.ispartof | Annals of Surgery | en |
dc.title | United states military cancer institute clinical trials group (USMCI GI-01) randomized controlled trial comparing targeted nodal assessment and ultrastaging with standard pathological evaluation for colon cancer | en |
dc.type | Conference Paper | en |
dc.identifier.doi | 10.1097/SLA.0b013e31826571c8 | en |
dc.identifier.pmid | 256 | en |
dc.identifier.scopus | 2-s2.0-84865470694 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84865470694 | en |
dc.relation.lastpage | 427 | en |
dc.relation.firstpage | 412 | en |
dc.relation.issue | 3 | en |
dc.relation.volume | 256 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Katedra za hirurgiju | - |
crisitem.author.dept | Katedra za pedijatriju | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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