Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/11735
DC Field | Value | Language |
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dc.contributor.author | Itzykson R. | en_US |
dc.contributor.author | Crouch S. | en_US |
dc.contributor.author | Travaglino E. | en_US |
dc.contributor.author | Smith A. | en_US |
dc.contributor.author | Symeonidis A. | en_US |
dc.contributor.author | Hellström-Lindberg E. | en_US |
dc.contributor.author | Sanz G. | en_US |
dc.contributor.author | Çermák J. | en_US |
dc.contributor.author | Stauder R. | en_US |
dc.contributor.author | Elena C. | en_US |
dc.contributor.author | Germing U. | en_US |
dc.contributor.author | Mittelman M. | en_US |
dc.contributor.author | Langemeijer S. | en_US |
dc.contributor.author | Madry K. | en_US |
dc.contributor.author | Tatic A. | en_US |
dc.contributor.author | Holm M. | en_US |
dc.contributor.author | Almeida A. | en_US |
dc.contributor.author | Aleksandar Savić | en_US |
dc.contributor.author | Šimec N. | en_US |
dc.contributor.author | Luño E. | en_US |
dc.contributor.author | Culligan D. | en_US |
dc.contributor.author | Guerci-Bresler A. | en_US |
dc.contributor.author | Malcovati L. | en_US |
dc.contributor.author | Van Marrewijk C. | en_US |
dc.contributor.author | Bowen D. | en_US |
dc.contributor.author | De Witte T. | en_US |
dc.contributor.author | Fenaux P. | en_US |
dc.date.accessioned | 2020-03-03T14:45:37Z | - |
dc.date.available | 2020-03-03T14:45:37Z | - |
dc.date.issued | 2018-08-28 | - |
dc.identifier.issn | 24739529 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/11735 | - |
dc.description.abstract | © 2018 by The American Society of Hematology. Prognosis of lower-risk (International Prognostic Scoring System [IPSS] low/intermediate-1) myelodysplastic syndrome (MDS) is heterogeneous and relies on steady-state assessment of cytopenias. We analyzed relative drops in neutrophil and platelet counts during the first 6 months of follow-up of lower-risk MDS patients. We performed a landmark analysis of overall survival (OS) of lower-risk MDS patients prospectively included in the European LeukaemiaNet MDS registry having a visit at 6 6 1 month from inclusion to assess the prognostic relevance of relative drops in neutrophils and platelets, defined as (count at landmark 2 count at inclusion)/count at inclusion. Of 2102 patients, 807 were eligible for the stringent 6-month landmark analysis. Median age was 73 years. Revised IPSS was very low, low, and intermediate/higher in 26%, 43%, and 31% of patients, respectively. A relative drop in platelets .25% at landmark predicted shorter OS (5-year OS, 21.9% vs 48.6% with platelet drop #25%, P, 1024), regardless of baseline IPSS-revised or absolute platelet counts. Relative neutrophil drop .25% had no significant impact on OS. We built a classifier based on red blood cell transfusion dependence (RBC-TD) and relative platelet drop .25% at landmark. Patients with none (62%), either (27%), or both criteria (11%) had 5-year OS of 53.3%, 32.7%, and 9.0%, respectively (P, 1024). This classifier was validated in an independent cohort of 335 patients. Combining relative platelet drop .25% and RBC-TD at 6 months from diagnosis provides an inexpensive and noninvasive way to predict outcome in lower-risk MDS. This study was registered at www.clinicaltrials.gov as #NCT00600860. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Blood Advances | en_US |
dc.subject | Prognostic Scoring System | en_US |
dc.subject | myelodysplastic syndrome | en_US |
dc.subject | neutrophil count | en_US |
dc.subject | platelet count | en_US |
dc.title | Early platelet count kinetics has prognostic value in lower-risk myelodysplastic syndromes | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1182/bloodadvances.2018020495 | - |
dc.identifier.pmid | 2 | - |
dc.identifier.scopus | 2-s2.0-85072746283 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85072746283 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 2089 | en_US |
dc.relation.firstpage | 2079 | en_US |
dc.relation.issue | 16 | en_US |
dc.relation.volume | 2 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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