Study of Quantitative Structure–Retention Relationships for s-Triazine Derivatives in Different RP HPTLC Systems

Abstract

Quantitative structure-retention relationships (QSRR) have been used to study the chromatographic behavior of some s-triazines. Retention factors, RM0, on C18 layers corresponding to zero percent organic modifier in the aqueous mobile phase were determined for five mobile phase mixtures: methanol-water, acetone-water, acetonitrile-water, 2-propanol-water, and tetrahydrofuran-water and relationships between RM0 values obtained with different organic mobile phase modifiers were examined. A variety of partition coefficients (Alog P, IAlog P, Clog P, Xlog P, log PKowin, and ACDlog P) were calculated by use of different software products. The correlation between partition coefficients and chromatographically obtained lipophilicity was analyzed. On the basis of correlations between RM0 and log P, C18 with methanol-water as mobile phase was selected as the best RP HPTLC system for determination of the octanol/water partition coefficient and thus the lipophilicity of the molecules.