Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/1099
DC Field | Value | Language |
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dc.contributor.author | Jeremić, Marija | en |
dc.contributor.author | Radovanović, Milan | en |
dc.contributor.author | Bisceglie F. | en |
dc.contributor.author | Kojić, Vesna | en |
dc.contributor.author | Jelić R. | en |
dc.contributor.author | Matović Z. | en |
dc.date.accessioned | 2019-09-23T10:13:32Z | - |
dc.date.available | 2019-09-23T10:13:32Z | - |
dc.date.issued | 2018-12-01 | en |
dc.identifier.issn | 2775387 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/1099 | - |
dc.description.abstract | © 2018 Elsevier Ltd Two new octahedral Rh(III) complexes that are potential chemotherapeutic agents have been synthesized from the 1,3-propanediamine-N,N,N’-triacetate ligand (1,3-pd3a): [Rh(1,3-pd3a)(H2O)]·2H2O (1) and Na[Rh(1,3-pd3a)Cl]·2H2O (2). Both complexes were characterized by IR, UV–Vis and NMR spectroscopy, as well as elemental analysis. Only the structure of 2 was determined by a single crystal X-ray diffraction study. The asymmetric unit contains the negatively charged rhodium complex, a sodium ion and two water molecules. The positions of the carboxylate groups define the cis-polar geometry. DFT calculations on 1 and 2 have also been done to confirm experimental results. In order to determine the protonation constants of 1,3-H3pd3a, stability constants and the stoichiometry of the complexes in aqueous solution, pH-potentiometry and UV–Vis spectrophotometry were used. Docking of 1 to human serum albumin (HSA) gives the reasonable assumption that this complex can be easily transported to the target cells. The complexes, as well as the 1,3-pd3a and ed3a ligands, were tested against various cancer and one normal human cell lines. Complex 2 and both ligands display significant cytotoxicity against the HeLa cancer cell line, while 1 shows good antitumor activity against MCF-7. Flow cytometry analysis showed the apoptotic death of the cells with cell cycle arrest in the G2/M phase (Na[Rh(1,3-pd3a)Cl]·2H2O) and G0/G1 phase (1,3-pd3a). | en |
dc.relation.ispartof | Polyhedron | en |
dc.title | Rhodium(III) in a cage of the 1,3-propanediamine-N,N,N′-triacetate chelate: X-ray structure, solution equilibria, computational study and biological behavior | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.doi | 10.1016/j.poly.2018.08.075 | en |
dc.identifier.scopus | 2-s2.0-85053773908 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85053773908 | en |
dc.relation.lastpage | 30 | en |
dc.relation.firstpage | 19 | en |
dc.relation.volume | 156 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Ekonomski fakultet, Departman za agrarnu ekonomiju i agrobiznis | - |
crisitem.author.dept | Medicinski fakultet | - |
crisitem.author.parentorg | Ekonomski fakultet | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
Appears in Collections: | EF Publikacije/Publications |
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