Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/10953
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jasna Mihailović | en_US |
dc.contributor.author | Ljubomir Stefanović | en_US |
dc.contributor.author | Milica Malešević | en_US |
dc.contributor.author | Branko Markoski | en_US |
dc.date.accessioned | 2020-03-03T14:42:12Z | - |
dc.date.available | 2020-03-03T14:42:12Z | - |
dc.date.issued | 2009-03-01 | - |
dc.identifier.issn | 10507256 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/10953 | - |
dc.description.abstract | Background: Differentiated thyroid carcinoma (DTC) usually has a good prognosis and rarely develops distant metastases. Although it might be expected that avid radioiodine uptake in distant metastases would be associated with a favorable outcome, there are few long-term studies regarding this. The present study was performed to evaluate the influence of radioiodine uptake in distant metastases on the disease-specific survival (DSS) in DTC patients. Methods: This retrospective study included 77 DTC patients with distant metastases (M1) who were treated with 131I therapy from 1977 to the end of 2000 in our institution. The median follow-up of patients was 6.1 years. Univariate and multivariate analysis were performed using the Kaplan-Meier method and log rank test, and Cox Regression model, respectively. Results: Seventy-seven patients with M1 included 51 (66.2%) women and 26 (33.8%) men; 32 (41.6%) patients were <45 years old and 45 (58.4%) patients were ≥45 years old (range: 8-70 years; mean age: 45.4 years); histologically, there were 54 (70.1%) papillary carcinomas, 22 (28.6%) follicular carcinomas, and one case (1.3%) with an inconclusive histological report. The probability of DSS after appearance of M1 was 57.95% after 5 years, 48.31% after 10 years, and 39.46% after 15 and 20 years. In patients with iodine-avid distant metastases the 5-year DSS was 66.54%, the 10-year DSS was 55.09%, and the 15- and 20-year DSS were 44.99%. In contrast, patients with non-iodine-avid lesions had a 5- and 10-year DSS of 18.33%. This difference relating to the relationship between 131I uptake in distant metastases and survival was significant (p = 0.0006). The proportion of patients with non-iodine-avid distant metastases that were ≥45 years old was significantly greater than the proportion of patients with non-iodine-avid distant metastases that were <45 years old (p < 0.01). If patients were matched for age, iodine non-avidity significantly shortened the survival in patients <45 years old (p < 0.001). According to multivariate analysis age had significantly greater influence on survival compared with iodine avidity (p < 0.001, p = 0.078, respectively). Conclusion: Patients with distant metastases have a long-term survival that depends, in addition to other factors, on age and the degree of radioiodine uptake in distant metastases. © Copyright 2009, Mary Ann Liebert, Inc. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Thyroid | en_US |
dc.subject | Differentiated thyroid carcinoma | en_US |
dc.subject | prognosis | en_US |
dc.subject | radioiodine avidity | en_US |
dc.title | The importance of age over radioiodine avidity as a prognostic factor in differentiated thyroid carcinoma with distant metastases | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1089/thy.2008.0186 | - |
dc.identifier.pmid | 19 | - |
dc.identifier.scopus | 2-s2.0-62249119221 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/62249119221 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 232 | en_US |
dc.relation.firstpage | 227 | en_US |
dc.relation.issue | 3 | en_US |
dc.relation.volume | 19 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za radiologiju | - |
crisitem.author.dept | Tehnički fakultet "Mihajlo Pupin" u Zrenjaninu, Katedra za informacione tehnologije | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Tehnički fakultet "Mihajlo Pupin" u Zrenjaninu | - |
Appears in Collections: | TFZR Publikacije/Publications |
SCOPUSTM
Citations
53
checked on May 10, 2024
Page view(s)
33
Last Week
12
12
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.