Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/10486
DC Field | Value | Language |
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dc.contributor.author | Injac R. | en_US |
dc.contributor.author | Bošković M. | en_US |
dc.contributor.author | Perse M. | en_US |
dc.contributor.author | Koprivec-Furlan E. | en_US |
dc.contributor.author | Cerar A. | en_US |
dc.contributor.author | Đorđević, Aleksandar | en_US |
dc.contributor.author | Strukelj B. | en_US |
dc.date.accessioned | 2020-03-03T14:39:48Z | - |
dc.date.available | 2020-03-03T14:39:48Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 17341140 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/10486 | - |
dc.description.abstract | Oxidative stress has an important role in the pathogenesis of doxorubicin (DOX)-induced nephrotoxicity. The aim of this study was to investigate the nephroprotective effects of fullerenol (FLR), an antioxidant agent, on DOX-induced nephrotoxicity. The investigation was carried out on adult female Sprague Dawley outbred rats with chemically induced breast cancer (1-methyl-1-nitrosourea; 50 mg/kg; ip). Rats were divided into the following groups: control healthy, control cancer, DOX alone (8 mg/kg, ip, cancer), DOX plus FLR as a pre-treatment (8 mg/kg and 100 mg/kg, respectively, ip, cancer), and FLR alone (100 mg/kg, ip, cancer). At the end of the 2nd day after drug administration, blood and kidney tissues were taken for analysis. The activity of lactate dehydrogenase and α-hydroxybutyrate dehydrogenase as serum enzymes, as well as level of malondialdehyde, glutathione, glutathione peroxidase, glutathione reductases, catalase and superoxide dismutase, were determined. DOX caused nephrotoxicity, but FLR pre-treatment prevented oxidative stress, lipid peroxidation and the disbalance of GSH/GSSG levels in kidney tissue caused by DOX. Our results confirm satisfactory nephroprotective efficacy of FLR in the acute phase of toxicity and encourage further studies regarding its use as a potential nephroprotector. Copyright © 2008 by Institute of Pharmacology Polish Academy of Sciences. | en |
dc.relation.ispartof | Pharmacological Reports | en |
dc.title | Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C-60(OH)(24) Via suppression of oxidative stress | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.scopus | 2-s2.0-57749186719 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/57749186719 | - |
dc.description.version | Unknown | en_US |
dc.relation.lastpage | 749 | en |
dc.relation.firstpage | 742 | en |
dc.relation.issue | 5 | en |
dc.relation.volume | 60 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.orcid | 0000-0003-4120-7318 | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
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