Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/10396
DC Field | Value | Language |
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dc.contributor.author | Miloš Vujanović | en_US |
dc.contributor.author | Nina Brkić Jovanović | en_US |
dc.contributor.author | Dalibor Ilić | en_US |
dc.contributor.author | Zorka Drvendžija | en_US |
dc.contributor.author | Biljana Srdić Galić | en_US |
dc.contributor.author | Vesna Turkulov | en_US |
dc.contributor.author | Snežana Brkić | en_US |
dc.contributor.author | Daniela Marić | en_US |
dc.date.accessioned | 2020-03-03T14:39:17Z | - |
dc.date.available | 2020-03-03T14:39:17Z | - |
dc.date.issued | 2019-08-07 | - |
dc.identifier.issn | 16089693 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/10396 | - |
dc.description.abstract | © 2019. The Authors. Background: Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease in mono-infected (without concomitant hepatitis B and/or C virus infection) people living with human immunodeficiency virus (HIV). The proper and on time identification of at-risk HIV-positive individuals would be relevant in order to reduce the rate of progression from NAFLD into non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Objectives: The aim of this study was to explore visceral fat thickness (VFT) and anthropometric measurements associated with the development of NAFLD in patients mono-infected with HIV and on long-standing combination antiretroviral therapy (cART). Method: Eighty-eight (n = 88) HIV-positive male patients, average age 39.94 ± 9.91 years, and stable on cART, were included in this prospective study. VFT was measured using ultrasonography. Anthropometric measurements included body mass index (BMI), waist-to-hip ratio (W/H), waist-to-height ratio (WHtR), waist and hip circumference (WC, HC). Differences between variables were determined using the chi-square test. The receiver operating characteristic (ROC) curve and the Youden index were used to determine optimal cut-off values of VFT and hepatic steatosis. The area under the curve (AUC), 95% confidence intervals, sensitivity and specificity are reported for the complete sample. Significance was set at p < 0.05. Results: Patients with steatosis had significantly higher values of BMI, HC, WC, W/H and WHtR. The VFT was higher in patients with steatosis (p < 0.001). Specifically, VFT values above 31.98 mm and age > 38.5 years correlated with steatosis in HIV-positive patients, namely sensitivity 89%, specificity 72%, AUC 0.84 (95% CI, 0.76–0.93, p < 0.001), with the highest Youden index = 0.61. The sensitivity of the age determinant above this cut-off point was 84%, specificity 73% and AUC 0.83 (95% CI, 0.75–0.92, p < 0.001), with the highest Youden index of 0.57. Conclusion: In the absence of more advanced radiographic and histological tools, simple anthropometric measurements and VFT could assist in the early identification of persons at risk of hepatic steatosis in low- and middle-income regions. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Southern African Journal of HIV Medicine | en_US |
dc.subject | Non-alcoholic fatty liver disease | en_US |
dc.subject | HIV mono-infection | en_US |
dc.subject | Hepatic steatosis | en_US |
dc.subject | Ultrasonography | en_US |
dc.subject | Anthropometric measurements | en_US |
dc.title | Associations of visceral fat thickness and anthropometric measurements with non-alcoholic fatty liver disease development in male patients mono-infected with human immunodeficiency virus | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.4102/sajhivmed.v20i1.968 | - |
dc.identifier.scopus | 2-s2.0-85072310595 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85072310595 | - |
dc.description.version | Published | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 20 | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | Katedra za psihologiju | - |
crisitem.author.dept | Katedra za anatomiju | - |
crisitem.author.dept | Katedra za anatomiju | - |
crisitem.author.dept | Katedra za infektivne bolesti | - |
crisitem.author.dept | Katedra za infektivne bolesti | - |
crisitem.author.dept | Katedra za infektivne bolesti | - |
crisitem.author.orcid | 0000-0001-7716-9072 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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File | Size | Format | |
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HIVMED-20-968.pdf | 632.82 kB | Adobe PDF | View/Open |
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