Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/10286
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Popović J. | en |
dc.date.accessioned | 2020-03-03T14:38:41Z | - |
dc.date.available | 2020-03-03T14:38:41Z | - |
dc.date.issued | 1984-01-01 | en |
dc.identifier.issn | 01634356 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/10286 | - |
dc.description.abstract | A method for determination of metoclopramide in serum, urine, and saliva is described that can be applied to both pharmacokinetic and clinical studies. Metoclopramide was extracted from alkalinised plasma into dichloro-methane and chromatographed on a Micro-Pak Si-5 column using a mobile phase of dichloromethane/methanol/diethylamine (89:10:1, by volume). The column was maintained at 25°C and the eluate monitored at 308 nm. The retention time for metoclopramide was 4.7 min. The limit of sensitivity in serum and urine was 15 nmol/L and 3 µmol/L, respectively, with coefficients of variation of 5.4 and 3.84%, respectively. Recovery was in the range of 93110% for serum and 94-103% for urine. The limit of sensitivity in saliva was 15 nmol/L. In more than 210 samples analyzed to date, the only drugs known to have interfered with the assay are β-adrenoceptor blockers (e.g., propranolol). The metabolites of metoclopramide did not interfere with the quantitation of the parent drug. © 1984 Raven Press, New York. | en |
dc.relation.ispartof | Therapeutic Drug Monitoring | en |
dc.title | High-pressure liquid chromatographic method for determination of metoclopramide in serum, urine, and saliva, with a pharmacokinetic study in patients | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.pmid | 6 | en |
dc.identifier.scopus | 2-s2.0-0021327630 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/0021327630 | en |
dc.relation.lastpage | 82 | en |
dc.relation.firstpage | 77 | en |
dc.relation.issue | 1 | en |
dc.relation.volume | 6 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Naučne i umetničke publikacije |
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