Normal and reversed-phase thin-layer chromatography of thiourea derivatives

Abstract

The chromatographic behavior of a series of differently substituted thiosemicarbazide and 1,2,4-triazoline-3-thione derivatives has been studied on silica gel, alumina and bonded C-18 silica gel layers with non-aqueous and aqueous - organic mobile phases. Retention data are discussed in relation to the molecular structure of the solute, and the nature of the stationary phase and eluent.